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KMID : 0545120200300081180
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Journal of Microbiology and Biotechnology
2020 Volume.30 No. 8 p.1180 ~ p.1183
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Prevalence and Characterization of Plasmid-Mediated Quinolone Resistance Determinants qnr and aac(6’)-Ib-cr in Ciprofloxacin-Resistant Escherichia coli Isolates from Commercial Layer in Korea
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Seo Kwang-Won
Lee Young-Ju
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Abstract
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The prevalence and characterization of plasmid-mediated quinolone resistance (PMQR) determinants in ciprofloxacin-resistant Escherichia coli isolated from a Korean commercial layer farm were studied. A total of 45 ciprofloxacin-resistant E. coli isolates were recovered and all isolates were multidrug-resistant. Eight isolates have the PMQR genes aac(6’)-Ib-cr, qnrS1, and qnrB4, and seven isolates exhibited double amino acid exchange at both gyrA and parC, and have high fluoroquinolone minimum inhibitory concentrations. Five transconjugants demonstrated transferability of PMQR and β-lactamase genes and similar antimicrobial resistance. Because PMQR genes in isolates from commercial layer chickens could enter the food supply and directly affect humans, control of ciprofloxacin resistance is needed.
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KEYWORD
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Antimicrobial resistance, commercial layer chicken, Escherichia coli, fluoroquinolones, plasmid-mediated quinolone resistance
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